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Diabetes

What is it?
Diabetes is a disorder characterized by high levels of glucose (sugar) in the blood and deficient glucose in the cells. Diabetes is epidemic in our country. Currently, 16,000,000 Americans suffer from diabetes and an estimated 80,000,000 more are at risk (one-quarter of the population of the United States!). Complications of diabetes are the seventh leading cause of death. These complications include blindness, peripheral neuropathy, cardiovascular and kidney disease, and gangrene of the feet and legs.

Complications of diabetes
Blood sugar is a good thing in small doses but can cause big problems in excess. A by-product of excessive glucose is a sugar called "sorbitol". Excessive accumulation of sorbitol in the eye leads to cataract formation. In fact, diabetic retinopathy is the leading cause of blindness in the United States, affecting one out of fifteen diabetics.
Excess sugar in the bloodstream contributes to atherosclerosis or hardening of the arteries. Diabetics have a two to three times higher risk of dying from heart attack or stroke than the average person. Diabetes raises cholesterol and triglycerides levels and also raises blood pressure. The reason for this is that the body is unable to burn glucose efficiently in the cells so the excess calories turn to fat and clog up the arteries. Fat clogging up the blood vessels also decreases the amount of oxygen available to the tissues. Red blood cells have to fold to fit into capillaries one at a time. Fat clumps blood cells together, preventing them from entering the capillaries and causing oxygen deprivation in the tissues. Increased fatty deposits on the artery walls also increase the resistance to blood flowing through these vessels, causing high blood pressure. High blood pressure and low tissue oxygenation contribute to other health problems.
Kidney disease is also common in diabetics and is one of the leading causes of death associated with diabetes. The high sugar levels cause destruction of the cells of the kidney that are responsible for filtering the blood and excreting wastes as urine. High blood pressure from diabetes also crushes the cells of the kidney leading to further damage. Many diabetics have to undergo kidney dialysis to replace the function of their damaged kidneys.
Male impotence is another effect of cardiovascular disease associated with diabetes. An erection requires normal blood pressure and the ability to shunt blood where it is needed. The cardiovascular problems noted above reduce or eliminate the ability to have erections sufficient to achieve orgasm.
The nerves that control function and tissue repair throughout the body are also damaged in diabetes, particularly in areas of poor circulation. Excess sorbitol in the peripheral nerves causes destruction of these nerves, leading to numbness, tingling and burning pain, especially in the legs and feet. Complete destruction of these nerves, in conjunction with reduced blood supply due to atherosclerosis, leaves the tissues vulnerable to injury, infection and tissue death (necrosis). Diabetic foot ulcers are an example of tissue dying from lack of proper nerve and oxygen-rich blood supply. In advanced cases of foot ulcers, the feet or even the lower limbs may have to be amputated to prevent the spread of gangrene (infection).

Types of diabetes
There are two main types of diabetes. Type I is also called "Juvenile onset" or "Insulin dependent" diabetes. Type II is called "Adult onset" or "Non-insulin dependent" diabetes mellitus. (NIDDM). A temporary form of diabetes sometimes occurs during pregnancy and is called, gestational diabetes.

Type I diabetes
As the name suggests, Type I or Juvenile onset diabetes generally occurs in children and is caused by a failure of the beta cells of the pancreas to produce insulin. Epidemiological evidence suggests that the beta cells are destroyed in an auto-immune reaction. Without beta cells, the body cannot produce insulin. Without insulin, blood sugar is unable to enter the cells of the body. The cells of the body are thus starved while blood sugar levels remain dangerously high. Symptoms of diabetes include increased thirst and urination, constant hunger, weight loss, blurred vision, and extreme fatigue. Since the brain requires glucose (sugar) to survive, if the diabetes is not diagnosed and treated with insulin, a person can lapse into a life-threatening diabetic coma. Because their bodies cannot make insulin, persons with Type I diabetes mellitus are called "insulin dependent diabetics" and must take insulin injections daily to control symptoms. This type of diabetes is also referred to as Insulin Dependent Diabetes Mellitus or IDDM.

Can anything be done to prevent Type I diabetes?
While the causes of Type I diabetes are not certain, risk factors have been identified. These causes include; maternal over-nutrition (excess calories), auto-immune reactions triggered by milk allergy or viral attack, and environmental toxins such nitrosamines found in cured or smoked meats.

Maternal nutrition
One of the strongest risk factors for both Type I and Type II diabetes is excessive food consumption by the mother during pregnancy. A study supporting this association was involved children born of mothers in post-war Berlin (1941-1948). There was limited food supply in Germany at this time due to post-war hardships and the cold war. Children born during in Berlin during this time period have less than 50% of the risk of diabetes as children born in other times. Another study demonstrated a significantly lower incidence of childhood diabetes during periods in which the blood sugar of the mother was closely controlled. The bottom line is that pregnant women should not over-eat.

Auto-immunity
The most widely accepted theory is that the body's own immune cells mistake the beta cells of the pancreas for foreign invaders and attack the beta cells when stimulated by a viral or allergic trigger. The pre-disposing factor for this immune system confusion is the genetic structure of the protein coat on white cells. The protein coating allows immune cells to tell the difference between "self" and "non-self". Just as red blood cells can be typed into A, B or O, according to their protein coatings, white blood cells can also be divided into HLA (Human Leucocyte Antibody) types. The white cell antibody type common in persons with diabetes is called HLA B8. A blood test can be performed to determine HLA types. Scientists think that a viral infection or allergy in sensitive individuals can over-stimulate the immune system, causing it to attack the beta cells of the pancreas.

Viruses are capable of infecting beta cells of the pancreas, stimulating an attack. Indirect evidence in support of this theory is that the onset of Type I diabetes is more common from October to March, the same period of time as viral infections are most frequent. A protein in milk (bovine albumin peptide) has also been linked to juvenile onset diabetes. Infants under four months of age who were exposed to cows milk or solid foods are 1.5 times more likely to develop Type I diabetes than infants who were exclusively breast fed. This is one more reason to breast feed your child. In families with a history of Type I diabetes, it may be advisable for nursing mothers to avoid consuming dairy products as the protein can pass into the mother's milk.

Consumption of smoked or cured meats containing N-nitroso compounds may be a risk factor as well. A diet high in bacon, ham, smoked salmon and similar products has been linked to Type I diabetes. Nitrosamines and other chemicals in foods or the environment have been implicated in beta-cell damage through free radical oxidation. Anti-oxidants such as vitamins A, E and C provide some protection against free radical destruction.

Type II diabetes
Type II diabetes ( also known as Non-Insulin Dependent Diabetes Mellitus or NIDDM) is more common, comprising 90 to 95% of cases of diabetes. It occurs as a result of over-consumption of highly processed foods and a lack of exercise. Incidence of Type II diabetes increases rapidly in persons over the age of 40 and is most common in adults over age 55. About 80 percent of people with type 2 diabetes are overweight. This form of diabetes is epidemic in our country and is rapidly affecting more young people due to a refined food diet and sedentary lifestyle. The most hopeful fact about adult-onset diabetes is that it is both preventable and at least partially controllable using good nutrition and exercise.

The reason Type II diabetes mellitus is also called non-insulin dependent diabetes is because the problem is not a lack of insulin as is the case with Type I diabetes. To the contrary, Type II diabetics typically have as much as four times the amount of insulin as their healthy counterparts. The problem instead is "tissue resistance" to insulin. In other words, insulin isn't as effective as it should be in getting glucose into the cells. To understand what this means, it is necessary to understand how insulin works in the first place.

Insulin and the cell membrane
Each cell is bordered by a semi-permeable membrane which serves to keep the cellular contents together and keep out unwanted materials, including excess glucose. The cell membrane is critically important in regulating what gets into and out of each cell. Insulin is like a key that opens a doorway in the cell membrane, allowing glucose to enter. Thus in Type I diabetes, each cell starves for lack of glucose despite high levels of glucose in the bloodstream.

So if a Type II diabetic has enough or even excessive insulin, why do Type II diabetics have a problem with blood sugar? The answer is that insulin isn't the only factor in determining how much glucose gets into the cells. Two other factors are also important: tissue demand for glucose and tri-valent chromium.

Obesity and lack of exercise
If a cell doesn't need glucose, it will not accept it. This lack of demand occurs with a sedentary lifestyle and obesity. A cell that is composed primarily of fat (stored energy) does not have any use for glucose. As obesity increases, there is generally a decrease in the percentage of cells such as muscle cells which are actively metabolizing glucose. A fat cell is "resistant" to insulin and glucose because a fat cell has no use for additional excess energy. Even in persons who are at a normal weight, lack of exercise still results in a gradual change in body composition from muscle to fat. People talk about "getting soft" especially around the waist with age, even if weight remains the same. This is because on average, people lose about half their muscle mass (which is replaced by fat) between ages 20 and 70. Less muscle means fewer cells that need glucose. Weight control becomes increasingly difficult as we get older precisely because we have fewer cells to burn up our calories. A healthy muscle cell that is at rest doesn't need much glucose either. Exercise can create such a strong demand for glucose that insulin isn't even needed to get into the cells. The glucose can enter the cell by direct osmosis if the cell is sufficiently depleted in glucose through exercise. Type II diabetes is often reversed by exercising back into a normal weight range and level of fitness.

The type of obesity associated with diabetes is called truncal obesity. This means that the fat is deposited on the trunk or upper body, especially around the waist. A narrow waist compared to the hips is attractive because it is a sign of good health. When the waist equals or exceeds the width of the hips, the person is at risk of diabetes and cardiovascular disease. Fat cells send a signal to the brain by secreting a hormone called leptin. This hormone signals the brain to eat more when the fat cell is being depleted of fat. These "hungry fat cell" signals are part of the reason it is so difficult to lose weight. Leptin also Research suggests that the amount of leptin in the blood is proportional to the amount of insulin in the blood and that persons with decreased insulin sensitivity therefor, have a harder time losing weight.

Chromium
Another important factor in getting glucose into the cell is chromium. This is because the cell membrane actually requires two keys to open the door into the cell (the "door" is called a sialic acid receptor). The other key is the mineral tri-valent chromium. This mineral is naturally found in whole grains and other natural foods but is refined out of our diet when we choose to eat sugar or white flour products such as white bread, pastries or pasta. In fact, eating refined carbohydrates increases urinary excretion of chromium by up to 300% This is one reason why Type II diabetes is most common in countries with a high consumption of refined carbohydrates.

Chromium deficiency is common in the United States. Taking supplemental chromium has been shown to significantly improve insulin function, decrease fasting glucose, cholesterol and triglyceride levels and also to increase beneficial HDL cholesterol. The protective role of chromium is further supported by the fact that diabetes is rare in Africa, China and other countries where whole, unrefined foods are the staples in the diet (other factors preventing diabetes in those countries include high-fiber, low calorie diets and exercise). Taking 200 to 500 mg of tri-valent chromium (also called GTF or "Glucose Tolerance Factor" chromium) can help control symptoms in persons deficient in chromium but is not enough to completely control or reverse diabetes. A good diet, exercise and possibly other nutritional supplements are also essential.

Refined carbohydrates, dietary fat and low fiber in the diet increases risk.

Fats
A diet high in fat, particularly saturated fat is strongly associated with increased risk of Type II diabetes. This is because the cell membrane is made of protein and fatty acids. The quality of dietary fat helps determine the quality of the cell membrane. Saturated fats and especially trans fats such as are found in margarine and many prepared foods make poor quality cell membranes. Essential fatty acids found in fish and flaxseed oil are needed to make the best quality cell membranes. Eating cold-water, ocean fish such as salmon, halibut and sardines twice a week and/or a TBS of flaxseed oil or 2TBS of fresh ground whole flaxseed per day will ensure an adequate supply of essential fatty acids. Equally important however, is to reduce or eliminate hydrogenated or trans fats and to reduce saturated fat and cholesterol. These fats, found in meats and dairy products, are stiff and hard at room temperature. Take a look in your frying pan after it cools the next time you cook a hamburger. The hard, white fat you see are saturated fats and cholesterol. Th e melting point of cholesterol is 325 degrees F. It will never be liquid in your body. Too high a cholesterol and saturated fat level in your body will produce stiff, inflexible cell membranes, unable to easily move materials into and out of the cell.

Refined carbohydrates
Sugar and refined carbohydrates increase risk of diabetes. They do so by causing a rapid rise in blood sugar levels, requiring large amounts of insulin to push the glucose into the cells. To compensate, the cells become less sensitive to insulin over time. Refined carbohydrates also deplete the body of needed vitamins and trace elements such as chromium because all these valuable nutrients are refined out of sugar and white flour products but are still needed by the body to effectively utilize the carbohydrates. In addition to white flour products such as breads, pasta, cookies, cakes, etc. and sugars such as in soft drinks, sweets and most fast food products, potatoes are absorbed as rapidly as refined sugar. The faster a food reaches the bloodstream as sugar the higher it is rated on the "glycemic index" scale. Sugars and refined products such as those listed above are called "high glycemic index" foods. To control your blood sugar, you want to eat foods with a low glycemic index. Carbohydrates with a low glycemic index include whole grains, beans, vegetables, nuts and seeds. These foods are low glycemic in part because they contain large amounts of fiber.

Fiber
A diet low in fiber also contributes to diabetes. What is fiber exactly? Fiber is the indigestible cell walls of plants. Especially good are plant fibers that are water soluble, such as are found in vegetables, beans, oat bran, nuts, seeds, psyllium seed husks, pears, apples and other fruits. Fiber is beneficial because it slows down the digestion and absorption of carbohydrates, leading to a slower rise in blood sugar levels. With a slower (and lower) rise in blood sugar levels, little insulin is needed to absorb the glucose into the cells. The cells then don't become desensitized to insulin. Diabetics (and everyone else) should consume enough fiber in their diet to produce one or two large (12 Ð 18 inch) bowel movements per day. Fresh ground flax seed comes to the rescue again as it is six times more absorptive than oat bran (which in itself is one of the very best sources of fiber).

How do doctors test for diabetes?
A blood test that measures the level of glucose is used to diagnose the presence and severity of diabetes. After a 12-hour fast, normal glucose levels range from 70 to 110 milligrams per dilution. Two measurements above 140 mg/dl indicate diabetes. Since blood sugar levels fluctuate, this test cannot measure occasional elevations above normal. People who have occasional elevations are at increased risk of developing adult-onset diabetes. The risk of developing adult-onset diabetes can be measured with a blood test called glycosylated hemoglobin. This test measures the amount of blood sugar that has combined with the protein in red blood cells. Since these cells live for 90 days, any elevation of blood sugar in the past 90 days will leave its mark on these cells. This combining of blood sugar with protein is the way that diabetes produces it's damaging effects on the body. Elevated glycosylated hemoglobin is one of the best five-year predictors of diabetes, heart disease and cancer.

How can I test myself for diabetes risk?
The simplest way to assess your risk for adult-onset diabetes is to measure your waistline. Essentially, your waist should be narrower than your hips. For women, the waistline should be no more than 80% of the measurement of the widest part of the hips. For men, the waist should be no more than 95% of the measurement of the widest part of the hips. Fat deposited around the middle indicates high risk for diabetes, heart disease and some forms of cancer. Being 30 pounds over-fat is another well known risk factor. This is not rocket science.

What can I do to control or reverse Type II diabetes?

Foods to avoid
Avoid sugar in all forms except for fresh fruit (not juice or dried fruit). Avoid or limit other low glycemic index foods such as white flour products and potatoes. Avoid trans fats such as margarine and limit saturated fats and cholesterol from meats and dairy products.

Avoid smoking and other nicotine products Insulin resistance is aggravated by smoking and other nicotine products. This is one more good reason to avoid smoking.

Foods to include
Fish, some chicken, turkey or other lean meats, whole grain products, beans, vegetables, fruits, berries, nuts and seeds. You can prepare many wonderful meals from this selection of foods. If you take care to use only whole, unrefined foods, cuisine's from Asia to the Mediterranean can be served from this selection of foods. One of the key factors common to each of these foods (in addition to a low glycemic index) is that they all contain generous amounts of fiber.

High fiber
Studies have been made of diabetics given supplemental fiber in their diet. Insulin dosages of diabetics on fiber supplemented diets can usually be reduced to one third the insulin dose of diabetics on the American Diabetes Association diets. Even more impressive is that approximately 60% of Type II diabetics on a high-fiber, low sugar, low fat diet are able to discontinue medication for blood sugar control while the remaining 40% are able to significantly reduce their dosage of medication. One of the best sources of supplemental fiber is fresh-ground flaxseed. Flaxseed has the added benefit of providing essential fatty acids.

Low amount (but high quality) of fats
The foods listed above are all low in fat, and the fats they contain are generally very high quality. The highest quality fatty acids are found in fresh, cold-water fish (sushi!) and flaxseed oil. Care must be taken with these beneficial oils to keep them fresh as they are easily damaged by heat, or prolonged exposure to light or air. You can use the flaxseed oil in salad dressing and serve the fish on the rare side. The reason these essential oils are good for you is that they keep the cell membranes fluid. By contrast, saturated fats (solid at room temperature) make cell membranes that are stiff and resistant to both glucose and insulin.

Olive oil is safe to heat and is the best oil for cooking (Virgin coconut oil is also excellent but more difficult to obtain). Monounsaturated fats such as olive oil have the added benefit of reducing body fat around the waist. In a study comparing persons consuming whole grains, vegetables, fruits, lean meats and monounsaturated fats, there was improved insulin sensitivity and decreased body fat in the upper body compared with individuals on the same diet but with less fat and more carbohydrate. Since obesity in the trunk is associated with Type II diabetes, this reduction in this type of body fat should improve insulin resistance and lower the risk of diabetes. Some tropical oils such as macadamia nut oil are also rich in monounsaturated fatty acids and could be used in place of olive oil.

Macronutient balance
The balance between carbohydrate, fat and protein in the diet can affect body composition and insulin resistance. In one study, a diet of 25% protein, 45% carbohydrate and 30% fat resulted in weight loss and fat loss were almost double that of a 12% protein, 58% carbohydrate and 30% fat diet. The higher protein group also enjoyed a greater reduction in triglycerides than the higher carbohydrate group.

Supplements


Chromium

A t a dose of 200 to 500 mcg, two times per day has been shown to help reduce blood sugar levels in diabetics who are deficient in chromium (see above).

Vitamin C
At doses of 2,000 mg per day have been shown to reduce sorbitol accumulation in the cells of diabetics. Researchers have found vitamin C more effective than the aldose reductase inhibiting drugs in lowering sorbitol levels. Vitamin C is also needed to support good immune function and healthy connective tissue, among other things. Taking 2,000 to 3,000 mg per day of vitamin C is also recommended to prevent atherosclerotic plaque buildup on the arteries.

Niacin or niacinamide
Use of niacin in the early years of Juvenile onset diabetes (IDDM) has resulted in lower insulin requirements, improved metabolic control and increased beta cell function. Some newly diagnosed Type I diabetics have shown a complete remission of their diabetes using 100 to 200 mg per day in children (the dose is 25 mg per kilogram). Niacin is also useful in lowering cholesterol levels. High doses of niacin produce a flushing of the skin that can feel like a sunburn. Many patients find this uncomfortable and prefer to take the slower-releasing form of niacin, called niacinamide. In cases where very high doses are desirable, such as to lower elevated cholesterol levels, a form of niacin called, inositol hexaniacinate is even better as dosages of 600 to 1,800 mg per day have not produced any side-effects. This dosage of inositol hexacianate has produced an 18% reduction in total cholesterol, a 26% reduction in triglycerides and a 30% increase in the beneficial HDL cholesterol.

Omega-3 fatty acids.
Supplementation with fish oils or flaxseed oil, 1-2 tablespoons per day is essential for diabetics. In both animal and human studies, these fatty acids produced significant improvement in diabetes. These essential fatty acids work by making the cell membrane more sensitive to insulin and glucose.

Vitamin B6
Supplementation with vitamin B6 can protect against diabetic neuropathy. In fact, the symptoms of diabetic neuropathy and B6 deficient neuropathy are the same. In one study of women with gestational diabetes, ingestion of 100 mg of B6 for two weeks resulted in complete remission of the diabetes in 12 of 14 women in the study. The high sugar levels in diabetics causes the glucose to attach to proteins in red blood cells and other tissues. This process, called glycolysation, makes the proteins less functional. The amount of red blood cell glycolysation is also used to monitor the risk and progression of diabetes. B6 prevents or reduces the glycolysation of proteins.

Biotin
Another B vitamin, biotin enhances insulin sensitivity at the cell membrane and also increases the activity of glucokinase. Glucokinase is a liver enzyme that helps break down glucose, thus reducing high levels of blood sugar.

B12
Vitamin B12 is another useful nutrient in preventing or palliating peripheral neuropathy. Like B6, B12 deficiency also produces a form of peripheral neuropathy similar to that found in diabetics. Doses of 1,000 to 3,000 mcg per day are generally sufficient when taken by mouth, though more severe cases may require vitamin B12 injections.

Vitamin E
Cell membranes are made of lipids (fatty acids) which are vulnerable to oxidation by free radicals. Vitamin E is a powerful anti-oxidant that stabilizes cell membranes. Vitamin E also prevents the free radical oxidation that scars artery walls, setting the stage for arteriosclerosis, a common cause of death in diabetics. Diabetics appear to have a higher than normal requirement for vitamin E, probably in the range of 800 to 1,200 IU's per day. Subjects taking 1,350 IU's per day of vitamin E improved insulin sensitivity and glucose tolerance. Another study demonstrated persons with low dietary vitamin E intake were 3.9 times more likely to develop diabetes than persons with adequate vitamin E intake.

Magnesium
A normal mineral, magnesium is commonly deficient in the American diet and is essential in the energetic processes of the cell.
Magnesium deficiency can increase the risk of diabetic retinopathy and heart disease. B6 is necessary for magnesium to get into the cells, so both must be taken for best effect.

Potassium
Another normal mineral, potassium is found primarily in fresh fruits and vegetables. Potassium improves insulin sensitivity and secretion. Potassium also reduces the risk of heart and vascular disease and also cancer. The only caution is that diabetics with kidney disease need to be careful about consuming excessive amounts of potassium. A diet in whole foods that includes plenty of vegetables should provide adequate potassium. Supplemental potassium should only be taken under supervision of a physician or other health provider.

Manganese
This trace element is a cofactor in many enzyme systems involved in blood sugar control. Diabetics typically have about one-half the manganese levels of normal individuals. A dose of 30 mg per day should be adequate.

Zinc
This trace element is involved in nearly every stage of glucose metabolism, from synthesis, secretion and utilization. Zinc helps control excessive blood sugar and has a protective effect against beta cell destruction. Additionally, zinc is very important for wound healing and this is essential in diabetics as they have notoriously poor wound healing ability.

Flavenoids
These are vitamin C like molecules found in fresh fruits and vegetables. One flavenoid, quercetin, promotes insulin secretion and inhibits sorbitol accumulation in the cells. 30 to 60 mg per day is commonly used to supplement diabetics.

As you may have noticed, a diet rich in fresh, whole foods provides the vitamins and minerals noted above, though not always in the quantities described. Taking supplements alone is not enough to make up for the effects of a deficient diet or a diet full of refined carbohydrates and damaging fats described earlier.

Exercise
As noted earlier, exercise increases glucose uptake in the cells, which helps to stabilize blood sugar levels. Exercise also builds increased muscle mass. The more muscle you have, and the more efficient it is in utilizing glucose and fatty acids, the better you will be able to control blood sugar levels and reduce the risk of cardiovascular disease. A 30 minute walk, twice a day can do a great deal to lower blood sugar levels and improve well-being. Strength training with weights or other means can increase your lean body mass and provide more cells hungry for glucose. One of the best ways to reduce your risk of diabetes or to correct Type II (NIDDM) is to exercise to the point of reducing your waistline to 90% of your hip measurement (for men. The ratio for women is that your waist should not exceed 80% of your hip measurement). Nothing can make you feel good as quickly as exercise. Exercise is truly the fountain of youth.

Diet summary
Whole grains, fresh fruits and vegetables, cold-water fish, skinless poultry, beans, nuts and seeds. Use olive oil for cooking, flaxseed oil on salads.

Exercise summary
Mild aerobic activity such as walking 30 minutes, twice a day. Strength training two to four times per week. Supplement summary (check with your health care provider before beginning any supplements) GTF chromium 200 Ð 500 mcg per day Vitamin C 2,000 Ð 3,000 mg per day Niacinamide or Inositol hexacianate 600 Ð 1,800 mg per day Vitamin B6 100 Ð 200 mg per day Biotin 400 mg per day Vitamin B12 1,000 Ð 3,000 mcg per day Vitamin E 800 Ð 1,200 mg per day Magnesium 200 mg, three times per day Manganese 30 mcg per day Zinc 30 Ð 60 mcg per day

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