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Magnesium

Proper name Magnesium
Category Mineral
Functions Magnesium is involved in over 300 biochemical reactions. Most important involve energy production, nerve transmission, muscle relaxation, synthesis of DNA and RNA, temperature regulation, detoxification and the formation of health bones and teeth. Over 30 clinical trials indicate magnesium is a useful adjunct to a program of lowering blood pressure. Magnesium increases the elasticity of blood vessels, increases oxygenation to the heart muscle by improving the ability of the heart to contract, inhibits platelet aggregation, reduces blood clotting and blocks calcium uptake in the heart muscle. The effects of magnesium are similar to the effects of Aspirin, Coumadin, Procardia and ACE inhibitors such as Vasotec. Magnesium is nature's number one medication for the heart. Magnesium deficiency can result in sudden cardiac failure. Intravenous magnesium following heart attack can cause a 70% decrease in the death rate of heart attack patients during the month following the attack. Asthma is improved by magnesium supplementation. Low magnesium is associated with increased incidence of asthma. Pre-menstrual syndrome symptoms of cramping, pain and irritability are improved with magnesium supplementation. Muscle pain and stiffness are improved with magnesium supplementtation. Magnesium is useful in the treatment of insomnia and nervous stress. Constipation can be treated with magnesium.
RDA 350 mg per day for men and 300 mg per day for women.
Therapeutic dose Up to 1,000 mg per day.
Deficiency symptoms Diets high in refined carbohydrates, meat and dairy products are deficient in magnesium. The USDA estimates that approximately 75% of Americans do not ingest the RDA of magnesium. 25% of diabetics demonstrate low levels of magnesium. Cardiovascular disease including increased incidence of hypertension, atherosclerosis, heart attack and stroke are all associated with magnesium deficiency. Kidney stones (calcium not uric acid type), cardiac arrhythmia, muscle cramps, insomnia, fatigue, anxiety, confusion, depression, fatigue, loss of appetite and other GI disorders, "restless legs", nervousness and osteoporosis are also associated with magnesium deficiency.
Toxicity Magnesium acts as a laxative when taken in excess. Magnesium is also easily excreted by the kidneys. It is nearly impossible create toxicity with excess magnesium intake.
Best forms  Magnesium gluconate, citrate, chloride, acetate, lactate and aspartate are all highly absorbable
Food sources Magnesium is found in whole grains, nuts, soybeans, cocoa, seafood, peas and green vegetables.
Lab tests Serum and urine magnesium
Drug interactions The following drugs deplete magnesium: Benzthiazide, Bumetanide, Chlorothiazide, Chlorotrianisene, Chlortetracycline, Cholestyramine Resin, Corticosteroids, Demeclocycline, Diethylstilbestrol, Digoxin, Doxycycline, Estrogens (conjugated or esterified), Ethacrynic Acid, Furosemide, Hydrochlorthiazide, Hydroflumethiazide, Indapamide, Methyclothiazide, Metolazone, Minocycline, Oral Contraceptives, Oxytetracycline, Penicillamine, Polythiazide, Quinestrol, Quinethazone, Tetracyclines, Torsemide, Trichlormethiazide.
Nutrient interactions Magnesium can be depleted by excessive calcium intake. Magnesium can substitute for manganese in some biochemical reactions.
Metabolism

The average adult contains about 25 grams of magnesium. About 70% of bodily magnesium is combined with calcium and phosphorus in bone.



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